Romulus Ledbetter lives on the streets of New York, a tortured man who has lost everything. When Romulus stumbles upon a dead body he becomes convinced that the death is murder, but finds that he stands alone in his belief. Sure that uncovering the killer will help vanquish his own demons Romulus sets about his own investigation, his determination bordering on delusional obsession. Sign Of The Killer is a slick piece of thriller hokum starring the always watchable, if indiscriminate, Samuel Jackson.