In Puerto Rico, the scientist Will Foster (Keanu Reeves) is researching the transference of the brain memories of soldiers to a synthetic body in the laboratory where he works with his partner and friend Ed (Thomas Middleditch). The experiment does not work and the body is rejected by the donors, and the manager Jones (John Ortiz) is pressing Will telling that the government will shut down the experiment. While traveling with his family to Ed´s boat in a stormy night, Will has a car accident on the road and his beloved wife Mona (Alice Eve) and their three children die. Will calls Ed and convinces him to develop clones of his family members to transfer their memories. They have only four pods and the youngest daughter is sacrificed. Now Will needs to make his experiment work since he will not have a second chance.